Guatemala's highest court issued a ruling Wednesday blocking President Jimmy Morales' decision to unilaterally end a U.N. anti-corruption commission.

The commission, known by its Spanish initials as CICIG, has angered Morales by investigating him, his sons and his brother on accusations of corruption, which they deny.

Guatemala's Constitutional Court overruled Morales' decision after all-night deliberations on five appeals against the president's cancellation of the agreement with the United Nations.

Morales has argued the commission had violated Guatemala's sovereignty and violated the rights of suspects.

Given the government's refusal to guarantee the commission's security, the U.N. has withdrawn the comission's members

The court has tussled with Morales before over the commission, though he has sometimes tried to ignore its rulings. The court has said the commission's mandate is valid through 2019.

Guatemala's human rights prosecutor, Jordan Rodas, said Morales' administration has to obey the new ruling.

"The government is under obligation to comply," said Rodas, who presented one of the appeals to the court. "If it doesn't obey, that is a whole other matter, and would constitute a coup, because the cornerstone of the rule of law is respect for the judicial branch."

During its 11 years operating in Guatemala, CICIG has pressed corruption cases that have implicated some 680 people, including top elected officials, businesspeople and bureaucrats. The commission said in November that it has won 310 convictions and broken up 60 criminal networks.